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Reports in for Greyhound Bus Crash - CBS 47
Canada's Transsexual Fish: Are Humans to Blame? - TIME (blog)
Investigation Continues Into Woman Found Dead In Trunk - KGTV San Diego
Mom charged after newborn dies of meth intoxication - Atlanta Journal Constitution
Wescott Testimony - FOX 40 News WICZ TV
Cemetery pond death probed as accidental drowning - Billings Gazette
Lack Of Recovery In Prompts CVD To Reduce Guidance Further - Benzinga
Police: MLB Rockies president died of natural causes - CNN (blog)
Coroner: no foul play in death of man in river - Seattle Times
Man dies in Silver Springs motel; officials await report - Ocala
In vitro investigation of oxide nanoparticle and carbon nanotube toxicity and intracellular accumulation in A549 human pneumocytes. Posted by mblau3 to pubmed on Fri Nov 27 2009
Induction of apoptosis and absence of inflammation in rat lung after intratracheal instillation of multiwalled carbon nanotubes. Posted by mblau3 to pubmed on Fri Nov 27 2009
Effects of combustion-derived ultrafine particles and manufactured nanoparticles on heart cells in vitro. Posted by mblau3 to pubmed on Fri Nov 27 2009
Cyclophosphamide treatment causes impairment of sperm and its fertilizing ability in mice. Posted by hamiltonthorne to IVOS on Thu Jan 21 2010
Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells. Posted by mblau3 to pubmed on Thu Feb 04 2010
Preclinical studies on safety of fullerene upon acute oral administration and evaluation for no mutagenesis. Posted by mblau3 to pubmed on Thu Feb 04 2010
Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats. Posted by mblau3 to pubmed on Wed Mar 17 2010
Genome-wide analysis of BEAS-2B cells exposed to trivalent arsenicals and dimethylthioarsinic acid "Lung is a major target for arsenic carcinogenesis in humans by both oral and inhalation routes. However, the carcinogenic mode of action of arsenicals is unknown. We investigated the effects of inorganic arsenic (iAsIII), monomethylarsonous acid (MMAIII), dimethylarsinous acid (DMAIII) and dimethylthioarsinic acid (DMTA), a sulfur containing dimethyl arsenic metabolite, in human bronchial epithelial (BEAS-2B) cells. Cells were exposed to 3, 15 microM-iAsIII; 0.3, 1 microM-MMAIII; 0.2, 1 microM-DMAIII; 0.2, 0.9 microM-DMTA as non-cytotoxic and minimally cytotoxic ( approximately 20%) concentrations based on Neutral Red uptake assays after 24h of culture. Total RNA was isolated and gene expression analysis conducted using Affymetrix Human Genome 133 Plus 2.0 arrays. Differentially expressed genes (DEGs) were determined using a one-way ANOVA (p 90% of DEG altered in the low concentration were also changed at the high concentration. There was a clear dose-response seen in the number of DEGs for all four compounds. iAsIII showed the highest number of DEG at both concentrations (2708 and 123, high and low, respectively). 1749, 420 and 120 DEGs were unique to the high concentrations of iAsIII, MMAIII and DMAIII, respectively. Transferrin receptor is a common DEG in low concentration arsenical treated cells. Ingenuity Pathway Analysis revealed p53 signaling (E2F1 and 2, SERPIN), and cell cycle related genes (cyclin D1) were altered by the high concentrations of DMTA, MMAIII and iAsIII. Oxidative stress (DUSP1, GPX2, NQO1, GCLC) and NF-kappaB signaling (TLR4, NF-kappaB) pathways were changed by the high concentrations of MMAIII and iAsIII. The genes identified in this study can be a valuable tool to determine the mechanism of arsenic toxicity and cancer formation. A number of similarities were observed in the gene expression profiles of DMAIII and DMTA and also iAsIII and MMAIII. These findings reveal some biological effects of arsenicals that will aid in creating a better risk assessment model for arsenical-induced lung cancer." Posted by sarah999 to file-import-10-03-11 on Thu Mar 25 2010
Rhodanese, but not cystathionine-gamma-lyase, is associated with dextran sulfate sodium-evoked colitis in mice: a sign of impaired colonic sulfide detoxification? Posted by hgaskins to sulfide colitis dss IBD toxicity on Mon Apr 12 2010
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